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Orora Bioactive Collagen System is a serum + cream combination that offers highly effective anti-aging results backed by biotechnology and clinically certified results.

It is powered by a new and revolutionary ingredient called HumaColl21 (sH-polypeptide-121), the first of its kind 100% vegan collagen peptide that is structurally and functionally identical to human collagen type 21. 

With high concentrations of glycine and proline, two amino acids responsible for signalling our cells to produce more skin collagen, HumaColl21 is a polypeptide designed to penetrate the outer layers of our skin for direct absorption by skin cells.

In short, Orora Bioactive Collagen System increases skin firmness, elasticity, and collagen levels in as little as 2 weeks while decreasing wrinkle size and reducing redness.

So effective, it won the "Best Moisturizer For Dry Skin 2022" by Chatelaine/FASHION magazine out of 150 brands tested.

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"Better Anti-Aging Performance Than Vitamin C or Retinol..."

In 3rd party clinical studies, HumaColl21 stimulates:

Collagen production by 197%,
Fibronectin production by 151%
Elastin expression by 133%

These results show better anti-aging performance than vitamin C or retinol.

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Designer collagen that absorbs through our skin

Traditional animal collagen in serums and creams has been around for over 40 years.

The science is clear on this: They don’t work.

This is because collagen molecules are too large to penetrate the epidermis (your outer skin layer) and thus cannot be absorbed. It simply sits on top.

HumaColl21 DOES get absorbed by the skin because it is a designer collagen peptide that is designed from inception to have molecules (short chain amino acids) small enough for absorption. It was designed specifically to solve this problem.

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World's first truly vegan collagen

All forms of commercial collagen comes from one of 4 living organisms: cow, pig, fish or chicken.

There are no collagen from plants because plants do not possess the complete amino acid profile for collagen. It is biologically impossible.  This is why HumaColl21 is truly revolutionary. HumaColl21 is created from a fermentation process using a plant molecule as the seed. Because we have complete control of the fermentation process, we can design the amino acid profile to mimic any form of collagen. HumaColl21 is the only collagen in the world approved by the FDA for the claim "vegan collagen". 

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Biologically identical to  human collagen

The fermentation process allows us to mimic any collagen so why mimic animal collagen when we can create 100% biologically identical human collagen.

HumaColl21 is an exact match to human collagen type 21 in structure and in function. Our body cannot tell the difference between the collagen that we produce on our own, and HumaColl21. This is the key because human collagen type 21 is the protein that tells our body to keep producing new skin collagen.

 It is as close to as the "fountain of youth" as we can get!  

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Results of 4 week anti-aging study

We asked 32 women ages 26 to 65 to test the Orora Bioactive Collagen System for 29 days.  After 29 days, there was an average of 200% reduction in fine lines and wrinkles.
97% agree that after the first application, the skin feels moisturized and hydrated.

81% agree that the bioactive collagen serum increases skin elasticity.

75% agree that the bioactive collagen serum increases skin's firmness.

75% agree that the skin tone appears more luminous and radiant

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Key Active Anti-Aging Ingredients

The first of its kind, 100% vegan, biologically identical human collagen. It is bio-designed in California and is GMO-free certified. HumaColl21® shows, in clinical studies, that skin elasticity is increased by 107%. It is also proven to decrease wrinkle size and reduce redness. HumaColl21® is the key anti-aging component found in bioactive collagen serum and cream.


Also known as vitamin B3, niacinamide is a very effective skin-restoring ingredient that offers multiple benefits for aging and blemish-prone skin. Among these benefits is the ability to visibly improve the appearance of enlarged pores, uneven skin tone, fine lines, dullness, and a weakened skin surface.


Bifida ferment filtrate is a probiotic ingredient derived from a specific type of yeast obtained by the fermentation of Bifida bacteria. Research has shown this ingredient can help sensitized skin become less sensitive to environmental aggressors by strengthening its microbiome.

Bifida Ferment Filtrate

Hyaluronic acid has restorative abilities and can boost skins moisture content, soothe, and defend against moisture loss. It is capable of holding up to 1,000 times its own weight in water, making it an optimal hydrator for all skin types.

Hyaluronic Acid 

Four principal bioactive compounds in the plant extract Centella asiatica. This common asian botanical extract is sometimes referred to as tigers grass or gotu kola. A powerful antioxidant with noted skin soothing and healing properties.

Madecassoside, Asiaticoside, Madecassic Acid, Asiatic Acid

Derived from olives; It is the saturated portion of emollient ingredient squalene, which is a natural component of human skin sebum (oil). It is a wonderfully moisturizing ingredient as well as being a source of replenishing fatty acids and antioxidants.

Vegan Squalane


Send Us Your Questions

If the question that you are looking for is not listed, please send it to us and we will get back as soon as possible.

We've given you something mind-blowing to think about.  What is bio-identical Human collagen? Why do you call it Human collagen. Where does it come from? Is it actually vegan? Will it actually help me with my specific skin concerns?

All great questions and we're going to help answer them for you. That's why you've got a direct line to our team of skincare and collagen experts to answer any and all questions.  You are unique and skin care is personal, so let's get it right.

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Our Customers Say


Verified Buyer

Skin type: N/A
Age range: 24 to 35
Skin concerns: N/A

You need Orora now!

I have been using this system for 6 months and I will never go back to anything else. Before I had chronically dry skin and Orora has completely fixed it. Hydrates in a non-greasy way so it feels like nothing is on my skin (I HATE that residue feeling from most hydrating moisturizers). I haven’t struggled with fine lines or wrinkles yet, I just turned 27, but I have been told since using this product that I look 20 years old! Definitely brings back a glow to my skin that I didn’t have for the past 5ish years. When my boyfriend uses these products I always can tell because his skin looks flawless. This stuff makes you glow! My complexion has never looked so great. These are my favorite products ever!! Mini update: I’m running low so haven’t used the serum as consistently, but did last night for the first time in a few weeks and LITERALLY felt my skin tighten!

Kathy A.

Verified Buyer

Skin type: combination
Age range: 55 to 64
Skin concerns: aging, skin tone & texture, sensitive

I love this product.

It actually changed the texture, the feel of my skin alongside of reducing my signs of aging.The main thing for me was improving the texture. Reducing large pores and firming skin.It did that and so much more.


Verified Buyer

Skin type: dry & sensitive
Age range: 46 to 54
Skin concerns: aging, skin tone & texture, sensitive

WOW!!! I’m 46, I have very dry skin.

I have a hard time finding adequately moisturizing products and typically layer 3-4 serums, oils, creams to get enough. I am now down to cleanse, tone and these two products. Im actually shocked at the deep hydration I’m getting! Skin tone appears more even and plumped. Loving this new addition to Saranghe! Thank you!!!!